{"id":3301,"date":"2019-06-03T18:18:31","date_gmt":"2019-06-03T10:18:31","guid":{"rendered":"http:\/\/118.178.179.165\/?page_id=3301"},"modified":"2020-02-18T16:07:57","modified_gmt":"2020-02-18T08:07:57","slug":"whatis","status":"publish","type":"page","link":"https:\/\/www.enbio.cn\/tw\/whatis\/","title":{"rendered":"\u8a8d\u8b58\u5e79\u7d30\u80de"},"content":{"rendered":"

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\u8a8d\u8b58\u5e79\u7d30\u80de<\/h2>\n<\/div>
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\u5e79\u7d30\u80de\u662f\u4e00\u985e\u5177\u6709\u591a\u5411\u5206\u5316\u53ca\u81ea\u6211\u8907\u88fd\u80fd\u529b\u7684\u7d30\u80de\u65cf\u7fa4<\/span><\/h5>\n

\u4e00\u7a2e\u7d30\u80de\u8b8a\u6210\u5404\u7a2e\u4e0d\u540c\u529f\u80fd\u7684\u7d30\u80de\uff0c\u662f\u70ba\u300c\u591a\u5411\u5206\u5316\u300d\uff1b\u4e00\u500b\u7d30\u80de\u8b8a\u6210\u6578\u500b\u81f3\u5343\u842c\u500b\u7d30\u80de\uff0c\u662f\u70ba\u300c\u81ea\u6211\u8907\u88fd\u300d\u3002\u80da\u80ce\u767c\u80b2\u904e\u7a0b\u4e2d\uff0c\u5e79\u7d30\u80de\u5206\u5316\u6210\u5404\u5f0f\u5404\u6a23\u7684\u7d30\u80de\uff0c\u4e26\u9032\u4e00\u6b65\u69cb\u6210\u5404\u7a2e\u8907\u96dc\u7684\u7d44\u7e54\u548c\u5668\u5b98\u3002<\/p>\n

\u500b\u9ad4\u767c\u80b2\u6210\u719f\u5f8c\uff0c\u5e79\u7d30\u80de\u4ecd\u5b58\u5728\u65bc\u8eab\u9ad4\u5404\u500b\u90e8\u4f4d\u4e2d\uff0c\u5305\u62ec\u8166\u3001\u5fc3\u81df\u3001\u9aa8\u9ad3\u3001\u7259\u9f52\u3001\u5468\u908a\u8840\u3001\u8102\u80aa\u7b49\uff0c \u80a9\u8ca0\u7d44\u7e54\u8207\u5668\u5b98\u7684\u7d30\u80de\u66f4\u65b0\u53ca\u640d\u50b7\u4fee\u5fa9\u4e4b\u529f\u80fd\u3002<\/p><\/div><\/div><\/div><\/div><\/section><\/div>

\u4f9d\u5e79\u7d30\u80de\u7684\u5206\u5316\u6f5b\u80fd\u53ef\u5206\u70ba\u4ee5\u4e0b\u56db\u5927\u985e<\/h2>\n<\/div>
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1.\u5168\u80fd\u5e79\u7ec6\u80de\uff08Totipotent stem cell\uff09<\/strong><\/span><\/h5>\n

\u5168\u80fd\u5e79\u7d30\u80de\u6307\u5177\u6709\u300c\u5b8c\u5168\u80fd\u529b\u300d\u7684\u5e79\u7d30\u80de\u3002\u5b83\u80fd\u5206\u5316\u6210\u4eba\u9ad4\u5404\u7d44\u7e54\uff0c\u4e26\u80fd\u9010\u6f38\u767c\u5c55\u6210\u4e00\u500b\u5b8c\u6574\u500b\u9ad4\uff0c\u4f8b\u5982\uff1a\u53d7\u7cbe\u5375\u3002<\/p>\n


\n2.\u842c\u80fd\u5e79\u7ec6\u80de\uff08Pluripotent stem cell\uff09<\/strong><\/span><\/h5>\n

\u842c\u80fd\u5e79\u7d30\u80de\u80fd\u5f62\u6210\u4eba\u9ad4\u5404\u7d44\u7e54\u7684\u7d30\u80de\uff0c\u4f46\u7121\u6cd5\u7368\u81ea\u767c\u5c55\u6210\u70ba\u500b\u9ad4\uff0c\u4f8b\u5982\uff1a\u80da\u80ce\u5e79\u7d30\u80de\u3002<\/p>\n


\n3.\u591a\u80fd\u5e79\u7d30\u80de\uff08Multipotent stem cell\uff09<\/strong><\/span><\/h5>\n

\u591a\u80fd\u5e79\u7d30\u80de\u53ea\u80fd\u5206\u5316\u6210\u67d0\u4e9b\u7279\u5b9a\u7d44\u7e54\u7684\u7d30\u80de\uff0c\u5982\u9020\u8840\u5e79\u7d30\u80de\uff08hematopoietic stem cell\uff09\u53ef\u5206\u5316\u6210\u8840\u7403\u53ca\u514d\u75ab\u7d30\u80de\u3002\u6b64\u985e\u5e79\u7d30\u80de\u7121\u6cd5\u96a8\u610f\u767c\u5c55\u6210\u5176\u4ed6\u7d44\u7e54\u53ca\u5b8c\u6574\u500b\u9ad4\u3002<\/p>\n


\n4.\u55ae\u80fd\u5e79\u7ec6\u80de\uff08Unipotent stem cell\uff09<\/strong><\/span><\/h5>\n

\u55ae\u80fd\u5e79\u7d30\u80de\u53ea\u80fd\u5206\u5316\u6210\u55ae\u4e00\u7d30\u80de\uff0c\u4f46\u4ecd\u5177\u6709\u81ea\u6211\u66f4\u65b0\u7684\u80fd\u529b\uff0c\u4f8b\u5982\u6dcb\u5df4\u5e79\u7d30\u80de\u53ef\u5206\u5316\u6210\u6dcb\u5df4\u7403\u3002 \u55ae\u80fd\u5e79\u7d30\u80de\u53c8\u7a31\u524d\u9a45\u7d30\u80de\u3001\u82bd\u7d30\u80de\u6216\u662f\u6bcd\u7d30\u80de\u3002<\/p><\/div><\/div><\/div><\/div><\/section><\/div> [vc_column_text][\/vc_column_text]

\u4f9d\u5e79\u7d30\u80de\u7684\u7372\u53d6\u4f86\u6e90\u53ef\u5206\u70ba\u4ee5\u4e0b\u4e8c\u5927\u985e<\/h2>\n<\/div>
<\/span><\/div><\/header><\/div><\/div><\/div><\/section><\/div> [vc_toggle title=”1.\u80da\u80ce\u5e79\u7d30\u80de”]\u80da\u80ce\u5e79\u7d30\u80de\u7684\u4f86\u6e90\u70ba\u80da\u80ce\u5167\u4e4b\u7d30\u80de\u5718\u584a\uff0c\u5176\u73cd\u8cb4\u4e4b\u8655\u5728\u65bc\u5177\u6709\u80fd\u529b\u767c\u5c55\u6210\u4e00\u500b\u5b8c\u6574\u751f\u547d\u500b\u9ad4\u6240\u9700\u4e4b\u5404\u5f0f\u5404\u6a23\u4e0d\u540c\u7684\u7d30\u80de\u7d44\u7e54\u3002<\/p>\n

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\u6210\u9ad4\u5e79\u7d30\u80de\u6709\u5f88\u591a\u7a2e\u985e\uff0c\u5176\u4e2d\u9020\u8840\u5e79\u7d30\u80de (HSC, hematopoietic stem cells) \u4ee5\u53ca\u9593\u8cea\u5e79\u7d30\u80de(MSC, mesenchymal stem cell) \u5df2\u6709\u591a\u5e74\u7814\u7a76\u7684\u6210\u679c\u3002\u9020\u8840\u5e79\u7d30\u80de\u7684\u4e3b\u8981\u529f\u80fd\u70ba\u5206\u5316\u6210\u4e0d\u540c\u7684\u8840\u7403\uff1a \u5305\u542b\u7d05\u8840\u7403\u3001\u8840\u5c0f\u677f\u8ddf\u5404\u7a2e\u767d\u8840\u7403\u7b49\u3002\u9593\u8cea\u5e79\u7d30\u80de\u4e3b\u8981\u529f\u80fd\u70ba\u5206\u5316\u6210\u8840\u7403\u4ee5\u5916\u7684\u7d30\u80de\uff0c\u5982\u9aa8\u982d\u3001\u8102\u80aa\u3001\u808c\u8089\u3001\u795e\u7d93\u7b49\u3002<\/p>\n

\u6210\u9ad4\u5e79\u7d30\u80de\u5b58\u5728\u8eab\u9ad4\u5404\u5668\u5b98\u7d44\u7e54\u4e2d\uff0c\u5176\u4e2d\u5728\u9aa8\u9ad3\u53ef\u4ee5\u5f97\u5230\u6578\u91cf\u591a\u4e14\u7a2e\u985e\u591a\u7684\u7d30\u80de\uff08\u9020\u8840\u5e79\u7d30\u80de\u8207\u9593\u8cea\u5e79\u7d30\u80de\u90fd\u6709\uff09\uff0c\u4e0d\u904e\u76f8\u5c0d\u7684\uff0c\u76f4\u63a5\u62bd\u53d6\u9aa8\u9ad3\u9700\u5168\u8eab\u9ebb\u9189\uff0c\u4fb5\u5165\u6027\u9ad8\u4e14\u9700\u4f4f\u9662\u89c0\u5bdf\uff0c\u6062\u5fa9\u8f03\u6162\uff0c\u98a8\u96aa\u8f03\u5927\u3002\u5176\u9918\u50cf\u662f\u900f\u904e\u63a1\u96c6\u81cd\u5e36\u8840\u6216\u662f\u5468\u908a\u8840\u5f97\u5230\u7684\u5e79\u7d30\u80de\uff0c\u524d\u8005\u7919\u65bc\u81cd\u5e36\u8840\u91cf\u7684\u9650\u5236\uff0c\u96d6\u7136\u81cd\u5e36\u8840\u4e5f\u540c\u6642\u542b\u6709\u9020\u8840\u5e79\u7d30\u80de\u8207\u9593\u8cea\u5e79\u7d30\u80de\uff0c\u4f46\u56e0\u8840\u91cf\u5c11\uff0c\u6240\u4ee5\u7d30\u80de\u6578\u91cf\u4e5f\u5c11\u3002<\/p>\n

\u5468\u908a\u8840\u5e79\u7d30\u80de\u76ee\u524d\u53d6\u5f97\u65b9\u5f0f\u662f\u5148\u65bd\u6253G-CSF\u767d\u8840\u7403\u751f\u9577\u7d20\uff0c\u9a45\u52d5\u5e79\u7d30\u80de\u5f9e\u9aa8\u9ad3\u79fb\u52d5\u51fa\u4f86\u4e26\u91cb\u653e\u5230\u5468\u908a\u8840\u6db2\u4e2d\uff0c\u4f7f\u5f97\u5468\u908a\u8840\u6db2\u4e2d\u5e79\u7d30\u80de\u6578\u91cf\u63d0\u5347\u81f3\u767e\u500d\uff0c\u518d\u4f7f\u7528\u5468\u908a\u8840\u6db2\u5e79\u7d30\u80de\u5206\u96e2\u8853\uff0c\u5c07\u5e79\u7d30\u80de\u5206\u96e2\u51fa\u4f86\u3002\u6b64\u904e\u7a0b\u985e\u4f3c\u6350\u8840\uff0c\u5b89\u5168\u6027\u9ad8\uff0c \u5f97\u5230\u7684\u7d30\u80de\u6578\u91cf\u53ca\u7a2e\u985e\u591a\u4e14\u54c1\u8cea\u4f73\uff0c\u61c9\u7528\u5ee3\u4e14\u526f\u4f5c\u7528\u4f4e\uff0c\u6240\u4ee5\u76ee\u524d\u6210\u9ad4\u5e79\u7d30\u80de\u7684\u4f86\u6e90\u4ee5\u63a1\u96c6\u5468\u908a\u8840\u70ba\u4e3b\u3002<\/p>\n

\u9664\u4e86\u6210\u9ad4\u5e79\u7d30\u80de\u4e4b\u5916\uff0cVSEL\u2122\uff08Very Small Embryonic-like Stem Cells\u975e\u5e38\u5fae\u5c0f\u985e\u80da\u80ce\u5e79\u7d30\u80de\uff09\u8fd1\u5e74\u4f86\u6b63\u53d7\u5230\u5168\u7403\u7814\u7a76\u4eba\u54e1\u7684\u77da\u76ee\u30022006\u5e74\uff0c\u7f8e\u570b\u8def\u6613\u58eb\u7dad\u723e\u5927\u5b78James Graham Brown\u764c\u75c7\u4e2d\u5fc3\u5e79\u7d30\u80de\u7814\u7a76\u6240\u4e3b\u4efbMariusz Ratajczak\u535a\u58eb\u767c\u73fe\u9aa8\u9ad3\u4e2d\u5b58\u5728\u8457\u4e00\u985e\u6578\u91cf\u7a00\u5c11\u7684\u842c\u80fd\u5e79\u7d30\u80de\uff0c\u5176\u9ad4\u7a4d\u975e\u5e38\u5c0f\uff0c\u5177\u6709\u985e\u4f3c\u80da\u80ce\u5e79\u7d30\u80de (ESC, Embryonic Stem Cells) \u7684\u5206\u5316\u80fd\u529b\uff0c\u56e0\u6b64\u547d\u540d\u70baVSEL\u2122\uff08Very Small Embryonic-like Stem Cells\u975e\u5e38\u5fae\u5c0f\u985e\u80da\u80ce\u5e79\u7d30\u80de\uff09\u3002\u79d1\u5b78\u5bb6\u767c\u73fe\uff0cVSEL\u2122\u5f9e\u80da\u80ce\u767c\u80b2\u6642\u671f\u5c31\u4e00\u76f4\u4ee5\u300c\u4f11\u7720\u72c0\u614b\u300d\u5132\u5099\u5728\u4eba\u9ad4\u5167\uff0c\u7576\u8eab\u9ad4\u7d44\u7e54\u6709\u53d7\u50b7\u7684\u60c5\u6cc1\u4e0b\uff0c\u5b83\u5c31\u6703\u79fb\u52d5\u5230\u5468\u908a\u8840\u4e2d\u5e6b\u52a9\u4fee\u5fa9\u53d7\u640d\u7d44\u7e54\uff0c\u5177\u6709\u91cd\u5efa\u591a\u7a2e\u7d44\u7e54\u7684\u80fd\u529b\u3002\u8a31\u591a\u7f8e\u570b\u7684\u81e8\u5e8a\u5be6\u9a57\u4e5f\u8b49\u660eVSEL\u2122\u53ef\u4ee5\u4fee\u5fa9\u5fc3\u808c\u6897\u585e\u60a3\u8005\u53d7\u640d\u7684\u5fc3\u808c\u3002\u79d1\u5b78\u5bb6\u76f8\u4fe1VSEL\u2122\u80fd\u9054\u5230\u80da\u80ce\u5e79\u7d30\u80de\u76f8\u540c\u7684\u6b63\u9762\u6548\u76ca\uff0c\u537b\u4e0d\u6703\u843d\u5165\u80da\u80ce\u5e79\u7d30\u80de\u7684\u502b\u7406\u53ca\u9053\u5fb7\u56f0\u5883\u3002 VSEL\u2122\u7684\u76f8\u95dc\u6280\u8853\u8207\u5c08\u5229\u70baCaladrius Biosciences\u5168\u7403\u7368\u5bb6\u64c1\u6709\u3002[\/vc_toggle][vc_column_text][\/vc_column_text]

\u5e38\u898b\u5e79\u7d30\u80de\u7684\u6bd4\u8f03<\/h2>\n<\/div>
<\/span><\/div><\/header><\/div><\/div><\/div><\/section><\/div> [vc_column_text]<\/p>\n
\u76ee\u524d\u5e02\u5834\u4e0a\u5145\u65a5\u8457\u8a31\u591a\u5e79\u7d30\u80de\u7684\u4f86\u6e90\u53ca\u8a0a\u606f\uff0c\u4e0d\u6b63\u78ba\u53ca\u4e0d\u5c0d\u7a31\u7684\u8cc7\u8a0a\u5b58\u5728\u6975\u5927\u7684\u98a8\u96aa\u53ca\u61c9\u7528\u4e0a\u7684\u9650\u5236<\/span><\/h5>\n

\u80da\u80ce\u5e79\u7d30\u80de\u6709\u7570\u9ad4\u6392\u65a5\u53ca\u764c\u5316\u7684\u98a8\u96aa\u4e14\u9053\u5fb7\u722d\u8b70\u5927\uff1biPS\u8a98\u5c0e\u578b\u5e79\u7d30\u80de\u7121\u6cd5\u63a7\u5236\u7d30\u80de\u5206\u5316\u7684\u901f\u5ea6\u53ca\u6578\u91cf\u6613\u5c0e\u81f4\u7d30\u80de\u8b8a\u7570\uff1b\u8102\u80aa\u5e79\u7d30\u80de\u5247\u5b58\u5728\u8457\u6975\u5927\u7684\u624b\u8853\u53ca\u8853\u5f8c\u4f75\u767c\u98a8\u96aa\u4ee5\u53ca\u6548\u679c\u6709\u9650\u7684\u554f\u984c\u7b49\u3002[\/vc_column_text][vc_column_text]<\/p>\n\n\n\n\n\n\n\n\n\n
\u7a2e\u985e<\/span><\/strong><\/td>\n\u4f86\u6e90<\/span><\/strong><\/td>\n\u53d6\u5f97\u65b9\u5f0f<\/span><\/strong><\/td>\n\u7f3a\u9ede\u53ca\u98a8\u96aa\u5206\u6790<\/span><\/strong><\/td>\n<\/tr>\n
\u80da\u80ce\u5e79\u7d30\u80de<\/td>\n\u80da\u80ce\u5167\u7d30\u80de\u5718\uff08\u7570\u9ad4\uff09<\/td>\n\u53d6\u53d7\u7cbe\u5375\u4e2d\u7684\u5167\u7d30\u80de\u5718\u4f86\u57f9\u990a<\/td>\n\n
    \n
  • \u7372\u53d6\u4f86\u6e90\u5c11<\/li>\n
  • \u6709\u7d30\u80de\u8b8a\u7570\u53ca\u81f4\u764c\u6027\u7b49\u98a8\u96aa<\/li>\n
  • \u9053\u5fb7\u722d\u8b70\u5927<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
iPS\u8a98\u5c0e\u578b\u5e79\u7d30\u80de<\/td>\n\u8868\u76ae\u7d30\u80de\u53cd\u5411\u8a98\u5c0e
\n\uff08\u81ea\u9ad4\uff09<\/td>\n		\u7531\u907a\u50b3\u57fa\u56e0\u5c0e\u5165\u76ae\u819a\u6210\u9ad4\u7d30\u80de\u4e2d\u88fd\u9020\u800c\u6210<\/td>\n\n
    \n
  • \u8a98\u5c0e\u6210\u529f\u56f0\u96e3\u5ea6\u9ad8<\/li>\n
  • \u6709\u7d30\u80de\u8b8a\u7570\u53ca\u81f4\u764c\u6027\u7b49\u98a8\u96aa<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\u7259\u9ad3\u5e79\u7d30\u80de<\/td>\n\u4e73\u7259\u3001\u7259\u9f66\u3001\u7259\u5468\u97cc\u5e36\u3001\u667a\u9f52
\n\uff08\u81ea\u9ad4\uff09<\/td>\n		\u81ea\u7136\u812b\u843d\uff08\u4e73\u7259\uff09\u6216\u4eba\u5de5\u53d6\u5f97\uff08\u7259\u9f66\u3001\u7259\u5468\u97cc\u5e36\u3001\u667a\u9f52\uff09<\/td>\n\n
    \n
  • \u55ae\u4e00\u7d30\u80de\uff0c\u5176\u61c9\u7528\u6027\u8f03\u70ba\u4fb7\u9650<\/li>\n
  • \u7d30\u80de\u6578\u91cf\u904e\u4f4e\uff0c\u9700\u8981\u4f7f\u7528\u6642\u4ecd\u9808\u7d93\u904e\u64f4\u589e<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\u9aa8\u9ad3\u5e79\u7d30\u80de<\/td>\n\u810a\u690e\u4e2d\u7684\u9aa8\u9ad3
\n\uff08\u81ea\u9ad4\u3001\u7570\u9ad4\uff09<\/td>\n		\u4ee5\u9aa8\u9ad3\u7a7f\u523a\u53d6\u5f97<\/td>\n\n
    \n
  • \u9aa8\u9ad3\u7a7f\u523a\u624b\u8853\u9700\u5168\u8eab\u9ebb\u9189\uff0c\u4fb5\u5165\u6027\u9ad8\uff0c\u98a8\u96aa\u8f03\u5927<\/li>\n
  • \u50b7\u53e3\u6613\u611f\u67d3\uff0c\u9700\u4f4f\u9662\u89c0\u5bdf\uff0c\u6062\u5fa9\u6642\u9593\u8f03\u9577<\/li>\n
  • \u7d30\u80de\u6578\u91cf\u53ca\u7a7f\u523a\u6b21\u6578\u6709\u9650<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\u8102\u80aa\u5e79\u7d30\u80de<\/td>\n\u8102\u80aa
\n\uff08\u81ea\u9ad4\uff09<\/td>\n		\u900f\u904e\u62bd\u8102\u624b\u8853\u5f8c\u53d6\u5f97<\/td>\n\n
    \n
  • \u55ae\u4e00\u7d30\u80de\uff0c\u5176\u61c9\u7528\u6027\u8f03\u70ba\u4fb7\u9650<\/li>\n
  • \u5206\u5316\u80fd\u529b\u8f03\u5dee<\/li>\n
  • \u7d30\u80de\u6578\u91cf\u904e\u4f4e\uff0c\u9700\u8981\u4f7f\u7528\u6642\u4ecd\u9808\u7d93\u904e\u64f4\u589e<\/li>\n
  • \u50b7\u53e3\u6613\u611f\u67d3<\/li>\n
  • \u8853\u5f8c\u6062\u5fa9\u6642\u9593\u8f03\u9577<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\u81ea\u9ad4\u5468\u908a\u8840\u9aa8\u9ad3\u5e79\u7d30\u80de<\/td>\n\u5468\u908a\u8840
\n\uff08\u81ea\u9ad4\uff09<\/td>\n		\u900f\u904e\u8840\u6db2\u5206\u96e2\u6a5f\u53d6\u5f97\uff0c\u53ef\u591a\u6b21\u6536\u96c6<\/td>\n\n
    \n
  • \u500b\u9ad4\u5dee\u7570\uff0c\u4f8b\u5982\u5c0dG-CSF\u7684\u53cd\u61c9\u3001\u8eab\u9ad4\u72c0\u6cc1\u7b49\uff0c\u6703\u76f4\u63a5\u5f71\u97ff\u5e79\u7d30\u80de\u7684\u6578\u91cf<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    ,[\/vc_column_text][\/vc_column][\/vc_row]<\/p>","protected":false},"excerpt":{"rendered":"

    [vc_row][vc_column][vc_column_text][\/vc_column_text][vc_toggle title=”1.\u80da\u80ce\u5e79\u7d30\u80de”]\u80da\u80ce\u5e79\u7d30\u80de\u7684\u4f86\u6e90\u70ba\u80da\u80ce\u5167\u4e4b\u7d30\u80de\u5718\u584a\uff0c\u5176\u73cd\u8cb4\u4e4b\u8655\u5728\u65bc\u5177\u6709\u80fd\u529b\u767c\u5c55\u6210\u4e00\u500b\u5b8c\u6574\u751f\u547d\u500b\u9ad4\u6240\u9700\u4e4b\u5404\u5f0f\u5404\u6a23\u4e0d\u540c\u7684\u7d30\u80de\u7d44\u7e54\u3002 \u7136\u800c\u80da\u80ce\u5e79\u7d30\u80de\u7372\u53d6\u4f86\u6e90\u5c11\uff0c\u4ea6\u5b58\u5728\u7d30\u80de\u8b8a\u7570\u53ca\u81f4\u764c\u6027\u7b49\u98a8\u96aa\uff0c\u4e14\u6d89\u53ca\u975e\u5e38\u5927\u7684\u9053\u5fb7\u722d\u8b70\uff0c\u76ee\u524d\u4e16\u754c\u5404\u570b\u53ea\u5141\u8a31\u6975\u5c0f\u7bc4\u570d\u7684\u7814\u7a76\u3002[\/vc_toggle][vc_toggle title=”2. \u6210\u9ad4\u5e79\u7d30\u80de”]\u6210\u9ad4\u5e79\u7d30\u80de\u662f\u5b58\u7559\u65bc\u80ce\u5152\u548c\u6210\u4eba\u7d44\u7e54\u5668\u5b98\u4e2d\uff0c\u4ecd\u4fdd\u6709\u751f\u9577\u4e26\u5206\u5316\u6210\u5176\u4ed6\u7a2e\u985e\u7d30\u80de\u80fd\u529b\u7684\u7d30\u80de\u3002\u7576\u4eba\u5471\u5471\u589c\u5730\u5f8c\uff0c\u662f\u6210\u9ad4\u5e79\u7d30\u80de\uff08Adult Stem Cell\uff0cASCs\uff09\u5728\u7dad\u6301\u8eab\u9ad4\u7684\u5065\u5eb7\u53ca\u6b63\u5e38\u904b\u4f5c\u3002\u6b63\u5e38\u60c5\u6cc1\u4e0b\u6210\u9ad4\u5e79\u7d30\u80de\u8655\u65bc\u975c\u6b62\u72c0\u614b\uff0c\u7576\u4eba\u9ad4\u51fa\u73fe\u640d\u50b7\uff0c\u6210\u9ad4\u5e79\u7d30\u80de\u6703\u8b8a\u6210\u53d7\u50b7\u90e8\u4f4d\u7684\u524d\u9a45\u7d30\u80de\uff0c\u4fee\u5fa9\u640d\u50b7\u3002\u7531\u65bc\u6210\u9ad4\u5e79\u7d30\u80de\u6c92\u6709\u6d89\u53ca\u9053\u5fb7\u502b\u7406\u4e0a\u7684\u554f\u984c\uff0c\u4ee5\u53ca\u672a\u4f86\u7528\u5728\u81ea\u9ad4\u8eab\u4e0a\u4e5f\u4e0d\u6703\u5f15\u767c\u514d\u75ab\u6392\u65a5\u7684\u56f0\u64fe\uff0c \u76ee\u524d\u4e16\u754c\u7684\u7814\u7a76\u65b9\u5411\u4ee5\u6210\u9ad4\u5e79\u7d30\u80de\u70ba\u4e3b\u3002 \u6210\u9ad4\u5e79\u7d30\u80de\u6709\u5f88\u591a\u7a2e\u985e\uff0c\u5176\u4e2d\u9020\u8840\u5e79\u7d30\u80de (HSC, hematopoietic stem cells) \u4ee5\u53ca\u9593\u8cea\u5e79\u7d30\u80de(MSC, mesenchymal stem cell) 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\u6210\u9ad4\u5e79\u7d30\u80de\u5b58\u5728\u8eab\u9ad4\u5404\u5668\u5b98\u7d44\u7e54\u4e2d\uff0c\u5176\u4e2d\u5728\u9aa8\u9ad3\u53ef\u4ee5\u5f97\u5230\u6578\u91cf\u591a\u4e14\u7a2e\u985e\u591a\u7684\u7d30\u80de\uff08\u9020\u8840\u5e79\u7d30\u80de\u8207\u9593\u8cea\u5e79\u7d30\u80de\u90fd\u6709\uff09\uff0c\u4e0d\u904e\u76f8\u5c0d\u7684\uff0c\u76f4\u63a5\u62bd\u53d6\u9aa8\u9ad3\u9700\u5168\u8eab\u9ebb\u9189\uff0c\u4fb5\u5165\u6027\u9ad8\u4e14\u9700\u4f4f\u9662\u89c0\u5bdf\uff0c\u6062\u5fa9\u8f03\u6162\uff0c\u98a8\u96aa\u8f03\u5927\u3002\u5176\u9918\u50cf\u662f\u900f\u904e\u63a1\u96c6\u81cd\u5e36\u8840\u6216\u662f\u5468\u908a\u8840\u5f97\u5230\u7684\u5e79\u7d30\u80de\uff0c\u524d\u8005\u7919\u65bc\u81cd\u5e36\u8840\u91cf\u7684\u9650\u5236\uff0c\u96d6\u7136\u81cd\u5e36\u8840\u4e5f\u540c\u6642\u542b\u6709\u9020\u8840\u5e79\u7d30\u80de\u8207\u9593\u8cea\u5e79\u7d30\u80de\uff0c\u4f46\u56e0\u8840\u91cf\u5c11\uff0c\u6240\u4ee5\u7d30\u80de\u6578\u91cf\u4e5f\u5c11\u3002 \u5468\u908a\u8840\u5e79\u7d30\u80de\u76ee\u524d\u53d6\u5f97\u65b9\u5f0f\u662f\u5148\u65bd\u6253G-CSF\u767d\u8840\u7403\u751f\u9577\u7d20\uff0c\u9a45\u52d5\u5e79\u7d30\u80de\u5f9e\u9aa8\u9ad3\u79fb\u52d5\u51fa\u4f86\u4e26\u91cb\u653e\u5230\u5468\u908a\u8840\u6db2\u4e2d\uff0c\u4f7f\u5f97\u5468\u908a\u8840\u6db2\u4e2d\u5e79\u7d30\u80de\u6578\u91cf\u63d0\u5347\u81f3\u767e\u500d\uff0c\u518d\u4f7f\u7528\u5468\u908a\u8840\u6db2\u5e79\u7d30\u80de\u5206\u96e2\u8853\uff0c\u5c07\u5e79\u7d30\u80de\u5206\u96e2\u51fa\u4f86\u3002\u6b64\u904e\u7a0b\u985e\u4f3c\u6350\u8840\uff0c\u5b89\u5168\u6027\u9ad8\uff0c \u5f97\u5230\u7684\u7d30\u80de\u6578\u91cf\u53ca\u7a2e\u985e\u591a\u4e14\u54c1\u8cea\u4f73\uff0c\u61c9\u7528\u5ee3\u4e14\u526f\u4f5c\u7528\u4f4e\uff0c\u6240\u4ee5\u76ee\u524d\u6210\u9ad4\u5e79\u7d30\u80de\u7684\u4f86\u6e90\u4ee5\u63a1\u96c6\u5468\u908a\u8840\u70ba\u4e3b\u3002 \u9664\u4e86\u6210\u9ad4\u5e79\u7d30\u80de\u4e4b\u5916\uff0cVSEL\u2122\uff08Very Small Embryonic-like Stem Cells\u975e\u5e38\u5fae\u5c0f\u985e\u80da\u80ce\u5e79\u7d30\u80de\uff09\u8fd1\u5e74\u4f86\u6b63\u53d7\u5230\u5168\u7403\u7814\u7a76\u4eba\u54e1\u7684\u77da\u76ee\u30022006\u5e74\uff0c\u7f8e\u570b\u8def\u6613\u58eb\u7dad\u723e\u5927\u5b78James Graham Brown\u764c\u75c7\u4e2d\u5fc3\u5e79\u7d30\u80de\u7814\u7a76\u6240\u4e3b\u4efbMariusz Ratajczak\u535a\u58eb\u767c\u73fe\u9aa8\u9ad3\u4e2d\u5b58\u5728\u8457\u4e00\u985e\u6578\u91cf\u7a00\u5c11\u7684\u842c\u80fd\u5e79\u7d30\u80de\uff0c\u5176\u9ad4\u7a4d\u975e\u5e38\u5c0f\uff0c\u5177\u6709\u985e\u4f3c\u80da\u80ce\u5e79\u7d30\u80de (ESC, Embryonic Stem Cells) \u7684\u5206\u5316\u80fd\u529b\uff0c\u56e0\u6b64\u547d\u540d\u70baVSEL\u2122\uff08Very Small Embryonic-like Stem Cells\u975e\u5e38\u5fae\u5c0f\u985e\u80da\u80ce\u5e79\u7d30\u80de\uff09\u3002\u79d1\u5b78\u5bb6\u767c\u73fe\uff0cVSEL\u2122\u5f9e\u80da\u80ce\u767c\u80b2\u6642\u671f\u5c31\u4e00\u76f4\u4ee5\u300c\u4f11\u7720\u72c0\u614b\u300d\u5132\u5099\u5728\u4eba\u9ad4\u5167\uff0c\u7576\u8eab\u9ad4\u7d44\u7e54\u6709\u53d7\u50b7\u7684\u60c5\u6cc1\u4e0b\uff0c\u5b83\u5c31\u6703\u79fb\u52d5\u5230\u5468\u908a\u8840\u4e2d\u5e6b\u52a9\u4fee\u5fa9\u53d7\u640d\u7d44\u7e54\uff0c\u5177\u6709\u91cd\u5efa\u591a\u7a2e\u7d44\u7e54\u7684\u80fd\u529b\u3002\u8a31\u591a\u7f8e\u570b\u7684\u81e8\u5e8a\u5be6\u9a57\u4e5f\u8b49\u660eVSEL\u2122\u53ef\u4ee5\u4fee\u5fa9\u5fc3\u808c\u6897\u585e\u60a3\u8005\u53d7\u640d\u7684\u5fc3\u808c\u3002\u79d1\u5b78\u5bb6\u76f8\u4fe1VSEL\u2122\u80fd\u9054\u5230\u80da\u80ce\u5e79\u7d30\u80de\u76f8\u540c\u7684\u6b63\u9762\u6548\u76ca\uff0c\u537b\u4e0d\u6703\u843d\u5165\u80da\u80ce\u5e79\u7d30\u80de\u7684\u502b\u7406\u53ca\u9053\u5fb7\u56f0\u5883\u3002 VSEL\u2122\u7684\u76f8\u95dc\u6280\u8853\u8207\u5c08\u5229\u70baCaladrius Biosciences\u5168\u7403\u7368\u5bb6\u64c1\u6709\u3002[\/vc_toggle][vc_column_text][\/vc_column_text][vc_column_text] \u76ee\u524d\u5e02\u5834\u4e0a\u5145\u65a5\u8457\u8a31\u591a\u5e79\u7d30\u80de\u7684\u4f86\u6e90\u53ca\u8a0a\u606f\uff0c\u4e0d\u6b63\u78ba\u53ca\u4e0d\u5c0d\u7a31\u7684\u8cc7\u8a0a\u5b58\u5728\u6975\u5927\u7684\u98a8\u96aa\u53ca\u61c9\u7528\u4e0a\u7684\u9650\u5236 \u80da\u80ce\u5e79\u7d30\u80de\u6709\u7570\u9ad4\u6392\u65a5\u53ca\u764c\u5316\u7684\u98a8\u96aa\u4e14\u9053\u5fb7\u722d\u8b70\u5927\uff1biPS\u8a98\u5c0e\u578b\u5e79\u7d30\u80de\u7121\u6cd5\u63a7\u5236\u7d30\u80de\u5206\u5316\u7684\u901f\u5ea6\u53ca\u6578\u91cf\u6613\u5c0e\u81f4\u7d30\u80de\u8b8a\u7570\uff1b\u8102\u80aa\u5e79\u7d30\u80de\u5247\u5b58\u5728\u8457\u6975\u5927\u7684\u624b\u8853\u53ca\u8853\u5f8c\u4f75\u767c\u98a8\u96aa\u4ee5\u53ca\u6548\u679c\u6709\u9650\u7684\u554f\u984c\u7b49\u3002[\/vc_column_text][vc_column_text] \u7a2e\u985e \u4f86\u6e90 \u53d6\u5f97\u65b9\u5f0f \u7f3a\u9ede\u53ca\u98a8\u96aa\u5206\u6790 \u80da\u80ce\u5e79\u7d30\u80de \u80da\u80ce\u5167\u7d30\u80de\u5718\uff08\u7570\u9ad4\uff09 \u53d6\u53d7\u7cbe\u5375\u4e2d\u7684\u5167\u7d30\u80de\u5718\u4f86\u57f9\u990a \u7372\u53d6\u4f86\u6e90\u5c11 \u6709\u7d30\u80de\u8b8a\u7570\u53ca\u81f4\u764c\u6027\u7b49\u98a8\u96aa \u9053\u5fb7\u722d\u8b70\u5927 iPS\u8a98\u5c0e\u578b\u5e79\u7d30\u80de \u8868\u76ae\u7d30\u80de\u53cd\u5411\u8a98\u5c0e … Continue reading 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